钻石国际

预约
挂号
联系
我们
就诊
指南
常见
问题
返回
顶部
请输入关键字
卢铀教授团队在Nature Medicine发表CRISPR基因编辑PD-1细胞治疗非小细胞肺癌临床研究成果 2020.04.28

2020NIAN4YUE27RI,WOYUANXIONGBUZHONGLIUKELUYOUJIAOSHOUTUANDUIZAINature Medicine (IF:30.641 )ZAIXIANFABIAOLETIWEI“Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer”DEYANJIUJIEGUO,BAODAOLELIYONGCRISPR-Cas9JIYINBIANJIJISHUZAITIWAITXIBAOZHONGBIANJIPD-1JIYIN,JINGTIWAITXIBAOPEIYANGKUOZENG,ZAISHUHUIFEIXIAOXIBAOFEIAI(NSCLC)SHOUSHIZHE,SHOUCIZHENGMINGLEGAILIAOFAZAINSCLCZHONGDEANQUANXINGHEKEXINGXING。DIYIZUOZHEJIANTONGXUNZUOZHEWEIWOYUANXIONGBUZHONGLIUKELUYOUJIAOSHOU,QITABINGLIEDIYIZUOZHEWEIXIONGBUZHONGLIUKEXUEJIANXINYANJIUYUAN、ZHOUXIAOJUANZHUZHIYISHI,WOYUANWEIDIYIZUOZHEDANWEI。

2016NIAN7YUE,《Nature》ZAZHILVXIANBAODAOLUYOUJIAOSHOUTUANDUIJIHUAKAIZHANSHOUGECRISPR–Cas9JIYINBIANJIRENTILINCHUANGSHIYAN,BINGYU2016NIAN10YUEJINXINGLESHOULISHOUSHIZHEZHILIAO。XIANGMUZUYANGEANZHAOLINCHUANGYANJIUFANGANJIHUA,SUIFANG2NIAN,JIEZHISHIJIANWEI2020NIAN1YUE31RI。GAILINCHUANGSHIYANWANCHENG12LISANXIANJIYISHANGZHILIAOSHIBAIDEWANQIFEIAIHUANZHEDEJIYINBIANJIXIBAOZHILIAO,RUZUSHOUSHIZHEANQUANXINGHENAISHOUXINGLIANGHAO,WU3JIJIYISHANGXIBAOZHILIAOXIANGGUANDUXINGFASHENGHEZHILIAOXIANGGUANXINGSIWANG。ZAIRUZUDE12LISHOUSHIZHEZHONG,ZHONGWEIWUJINZHANSHENGCUNSHIJIAN(PFS)WEI7.7ZHOU,ZHONGWEISHENGCUNSHIJIAN(OS) WEI42.6ZHOU。LINCHUANGPINGJIAWEIJIBINGWENDING(SD)2LIZHONG,YILISHOUSHIZHEWENDINGSHIJIANJIN18GEYUE。

GAILINCHUANGSHIYANHAIZHONGDIANYANJIUCRISPRJIYINBIANJIDUITXIBAOZHIPINDETUOBAXIAOYING,GAITUANDUIFENBIELIYONGERDAICEXUJISHU(NGS)HEQUANJIYINZUCEXUJISHU(WGS)DUIXIBAOZHIPINJINXINGTUOBAJIANCE。JIEGUOXIANSHIZHEIZHONGCRISPRJIYINBIANJIDAOZHIDETUOBAXIAOYINGSHIDITUBIANPINLVHUOBUCHANGJIANDE。

GAILINCHUANGYANJIUSHIYIXIANGZHUANHUAXINGIQILINCHUANGSHIYAN,QICHENGGUODEFABIAO,WEICRISPRJIYINBIANJIJISHUJINYIBUXIANGLINCHUANGYANJIUZHUANHUATIGONGLEZHONGYAOYIJU。



LUYOUJIAOSHOU,SICHUANDAXUEHUAXIYIYUANXIONGBUZHONGLIUKEZHUREN,BOSHISHENGDAOSHI,SICHUANSHENGWEISHENGJISHENGWEISHOUXIZHUANJIA。ZHUYAOYANJIUFANGXIANGWEIFEIAIBAXIANGZHILIAO、MIANYIZHILIAOYIJILITIDINGXIANGXIAORONGFANGSHEZHILIAO(SABR)DENGLINCHUANGSHIYANDESHEJIHESHISHI。DANRENZHONGGUORENLEIYICHUANZIYUANGUANLIPINGSHENZHUANJIAWEIYUANHUIWEIYUAN,CSCOFEIXIAOXIBAOFEIAIZHUANWEIHUIFUZHURENWEIYUANDENG。ZHONGGUO《YUANFAXINGFEIAIZHENLIAOGUIFAN》、《CSCOFEIAIZHINAN》JI《NCCN-YAZHOUFEIXIAOXIBAOFEIAIZHENZHIZHUANJIAGONGSHI》BIANZHIZHUANJIA。KEJIBU“SHIYI.WU”、“SHIER.WU”HE“SHISAN.WU”KEJIZHONGDAZHUANXIANGRENLEIZHONGDAJIBINGKETIHUOZIKETIFUZEREN,DUOXIANGGUOJIAZIRANKEXUEJIJINKETIFUZEREN。ZAINat Med,the Lancet  Oncol, J Clin Oncol, IROBP, Mol Ther DENGQIKANFABIAOSCILUNWEN80DUOPIAN。ZHUBIANZHUANZHU3BU,ZHUYI1BU。


作者:仝瑞占 编辑:史杰蔚 周亮 来源:胸部肿瘤科
基本信息填写
您的姓名:
联系方式:
电子邮箱:
问题类型:

select…

  • 内容无法访问
  • 信息不更新
  • 内容不准确
  • 错别字
  • 图片不准确
  • 其他
问题页面网址:
问题描述:
验证码: